060333220 TOXICOLOGY AND ENVIRONMENTAL HEALTH HAZARDS ( 3 Crd.Hrs )

Pre-Requisites : 060332001

Tens of thousands of chemicals are currently in common use. Hundreds are introduced newly every year. The toxic effects of these compounds on man, animals, and environment are the focus of the different disciplines of toxicology. Toxicologists study the toxicokinetics of compounds, their metabolism in the body, and their mechanism of action. Such information help policy makers decide at what dose a compound could be used safely. This course reviews the essentials of toxicology (dose response, absorption, distribution, metabolic conversion, and elimination), the molecular basis for toxic action, target organ toxicity, mutagenesis, teratogenesis, and carcinogenesis. Selected chemical agents that adversely affect human health are discussed. The concept of risk assessment is also introduced.