060712100 RADIOBIOLOGY ( 2 Crd.Hrs )

Pre-Requisites : 060712110, 100211620

This two credit hour course provides an introduction to principles and concepts underlying the biological effects of ionizing radiation at the molecular, cellular and whole-tissue level. Topics covered include selected aspects of microdosimetry, radiation damage to DNA, DNA repair mechanisms, cell-cycle kinetics (repopulation effects), cell death mechanisms and clonogenic survival, Linear Energy Transfer (LET) effects and relative biological effectiveness (RBE), oxygen effects, apoptosis, acute effects of whole body irradiation, radiation carcinogenesis, hereditary effects of radiation, the tumor control probability (TCP), clinical responses of normal tissues to radiation, cancer biology.