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In vitro evaluation of the biofunctionality of osteoblasts cultured on DegraPol-foam

Authors: 
B Saad, M Casotti, TH Huber, P Schmutz, M Welti, GK Uhlschmid, P Neuenschwander, UW Suter
Journal Name: 
Journal of Biomaterials Science, Polymer Edition
Volume: 
11
Issue: 
8
Pages From: 
787
To: 
800
Date: 
السبت, يناير 1, 2000
Abstract: 
The biofunctionality of osteoblasts cultured on DegraPol-foam, a biodegradable, elastic, and highly porous polyesterurethane-foam, was determined here to examine the possible use of this structure as bone repair material. Osteoblasts from rat tibia and from the cell line (MC3T3-E1) exhibited relatively high attachment and low doubling time that result in a confluent cell multilayer on the surface of the foam. They produced high concentrations of collagen type I and osteocalcin, and expressed increasing alkaline phosphatase activity. ...