Orthodontic tooth movement is mainly a biological response to a mechanical force. Tooth movement is induced by prolonged application of controlled mechanical forces which creates pressure and tension zones in the periodontal ligament and alveolar bone causing remodeling of tooth sockets. When a tooth is moved by application of orthodontic force, there is bone resorption on the pressure side and new bone formation on the tension side. Orthodontists often prescribe to manage pain from force application. However, analgesics block prostaglandin synthesis by inhibiting cyclooxygenase enzymes (COX)and results in slower tooth movement. Analgesics also have gastrointestinal side effects. The review describes the effect of analgesics, on orthodontic tooth movement.