Journal Name:
European journal of biochemistry
Volume:
213
Issue:
2
Pages From:
805
To:
814
Date:
Thursday, April 1, 1993
Abstract:
The influence of cell-substrata interactions on the preservation of basal or in-vivo-
induced micro-somal cytochrome P-450 isoenzyme contents in cultured rat hepatocytes and
on the adaptive responses after exposure to phenobarbital or 3-methylcholanthrene in vitro,
was investigated. Hepatocytes from untreated or phenobarbital-treated rats were cultured in
serum-free, aprotinin-supplemented culture medium in 96-well microtiter plates coated with
collagen type I (COL), laminin, fibronectin or crude liver membrane fractions/collagen type ...