Journal Name:
The FEBS Journal
Volume:
229
Issue:
2
Pages From:
349
To:
355
Date:
Saturday, April 1, 1995
Abstract:
The regulation of acute-phase protein production and nitric oxide (NO) release in
lipopolysaccharide-induced liver injury is thought to occur in response to monocytes/
macrophages and Kupfrer-cell-derived cytokines. In this study, we used primary cultured rat
hepatocytes maintained as a differentiated phenotype to investigate the direct effects of
endotoxin (lipopolysaccharide) on the production of the acute-phase proteins and on NO
release.