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Hypericum triquetrifolium Extracts Modulate IL-6, IL-10 and TNF-α Protein and mRNA Expression in LPS-Activated Human Peripheral Blood Mononuclear Cells and THP-1-Derived Macrophages

Authors: 
B Saad, WH Embaslat, B Abu-Farich, S Mahajna, M Azab
Journal Name: 
Med Aromat Plants S
Volume: 
3
Issue: 
1
Pages From: 
2167
To: 
412
Date: 
Friday, January 1, 2016
Abstract: 
Abstract The present in vitro study was carried out to evaluate the anti-inflammatory activity of Hypericum triquetrifolium extracts (HT-extract) on lipopolyssacharide-stimulated human monocytic (THP-1) cells and human peripheral blood mononuclear cells (PBMNCs). The expression and production of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6), as well as the anti-inflammatory cytokine interleukin 10 (IL-10) were evaluated by assessing the levels of proteins and mRNA's of TNF-α, IL-6 and IL-10 in both ...