ISSN:
2354-2152
Journal Name:
Evidence-Based Complementary and Alternative Medicine
Volume:
2022
Issue:
2832889
Pages From:
1
To:
42
Date:
Sunday, March 20, 2022
Abstract:
The growing smooth talk in the field of natural compounds is due to the ancient and current interest in herbal medicine and their
potentially positive effects on health. Dozens of antidiabetic natural compounds were reported and tested in vivo, in silico, and in
vitro. The role of these natural compounds, their actions on the insulin signaling pathway, and the stimulation of the glucose
transporter-4 (GLUT4) insulin-responsive translocation to the plasma membrane (PM) are all crucial in the treatment of diabetes
and insulin resistance. In this review, we collected and summarized a group of available in vivo and in vitro studies which targeted
isolated phytochemicals with possible antidiabetic activity. Moreover, the in silico docking of natural compounds with some of the
insulin signaling cascade key proteins is also summarized based on the current literature. In this review, hundreds of recent studies
on pure natural compounds that alleviate type II diabetes mellitus (type II DM) were revised. We focused on natural compounds
that could potentially regulate blood glucose and stimulate GLUT4 translocation through the phosphoinositide 3-kinase (PI3K)/
protein kinase B (Akt) pathway. On attempt to point out potential new natural antidiabetic compounds, this review also focuses
on natural ingredients that were shown to interact with proteins in the insulin signaling pathway in silico, regardless of their in
vitro/in vivo antidiabetic activity. We invite interested researchers to test these compounds as potential novel type II DM drugs
and explore their therapeutic mechanisms.
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